Naples Laser & Skin

Chemical formula	C₂₆H₂₅ClNO
Class	Triphenylethylene SERM — trans-clomiphene isomer
Molecular weight	≈ 405.9 g/mol
Available forms	Enclomiphene capsules Testosterone + Enclomiphene combination Formulation selected based on individual patient needs and provider judgment
Half-life	≈ 10 hours (considerably shorter than steroidal esters)
Rx status	Prescription only — requires licensed provider review of symptoms, medical history, current medications, and lab work prior to prescribing
Origin	Isolated as the active trans-isomer of clomiphene citrate, a fertility compound first developed mid-20th century

HOW IT WORKS

Enclomiphene works through hormone-signaling pathways — specifically by modulating estrogen receptors at the hypothalamic-pituitary axis, prompting the body's own signaling cascade to support endogenous testosterone production. It may be considered for appropriate patients after a provider reviews symptoms, medical history, current medications, and relevant labs. Your clinician will determine whether it is a suitable option and recommend a personalized treatment plan if appropriate.

WHAT TO EXPECT

Clinician-directed hormone care plans
Men's health and hormone optimization protocols
Compounding pharmacies (US-formulated)
Fertility-adjacent endocrinology practices

BEFORE YOU START

The active trans-isomer of clomiphene citrate — isolated for greater receptor selectivity than the racemic parent compound. Oral administration distinguishes it from injectable androgen therapies, making it a notable alternative in hormone care planning. Available as standalone capsules or in combination formulations with testosterone. All use requires a valid prescription and provider oversight, with dosing determined by individual lab work and clinical presentation.